BASIC RESPONSIBILITIES:
Employee will have in-depth knowledge of inflammatory and immunological disease, with experience in translational medicine. Being well versed in the scientific literature, employee will use current translational approaches to address questions of drug mechanism of action and explore disease-relevant outcomes, using a combination of in vitro methods and clinical laboratory technologies. In vivo studies may be coordinated through a separate research facility, contract research laboratories, or academic collaborations. Will be responsible for well-defined project(s) in dermatological, rheumatological, fibrotic or gastrointestinal conditions; will direct the efforts of support staff in carrying out research. Responsible for experimental design and interpretation of results. Will provide training to new staff and less experienced employees as necessary. Will act as scientific leader on those projects for which scientist is given primary responsibility, and make scientific presentations both internally and externally when appropriate. Employee will keep an electronic laboratory notebook, write quarterly status reports, author non-clinical pharmacology study reports, will support the patent process when sufficient scientific evidence is available to warrant pursuit by the company, and will write and publish peer-reviewed articles when appropriate and concordant with company interests.
SPECIFIC DUTIES:
1. Develop in vitro assays for testing activity of Celgene compounds in primary cell-based cultures, using patient samples whenever possible.
2. Study the intracellular signal transduction cascades within pertinent cell types to assess mechanism of action.
3. Compare new chemical entities in pharmacodynamic models to differentiate and optimize therapeutic usage strategies.
4. Lead a cross-functional multidisciplinary effort to develop compounds for inflammatory and immunological diseases on Project Development Teams.
5. Work with Scientists and Associate Scientists Research Associate, and under the direct but limited supervision of the Director.
6. Analyze, interpret, and report experimental results.
7. Establish and maintain working relationship with contract laboratories, academicians and consultants.
8. Responsible for the evaluation of subordinates and recommends promotions, merit increases and/or adjustments.
9. Ensure that the Translational Development Department maintains current awareness in area of expertise, enhances the scientific credibility of Celgene through contributions to the scientific literature (publications/presentations), through extramural activities and scientifically related interactions with academic authorities.
10. Assumes responsibility for writing quarterly status reports, non-clinical pharmacology study reports, invention disclosures, as well as portions of clinical study protocols, investigator brochures, and regulatory documents such as INDs and NDAs.
The position requires an individual with:
An advance graduate degree in a field of science related to inflammatory and autoimmune disease (Ph.D.) with at least 5 years of laboratory research experience, and at least 2 years of translational medicine experience in the industrial setting. Pharmacogenomics and data warehousing experience are a plus.
Excellent communication skills to effectively convey scientific concepts and data at the corporate level, with internal working groups/project teams and external academic and industrial organizations.
Team player, mentoring ability, excellent supervisory skills.
Qualifications
Skills/Knowledge Required:
ORGANIZATIONAL/JUDGEMENT:
The incumbent must have planning skills for scheduling activities and meeting project team deadlines. The position requires problem solving ability, people management ability and skills in resolving technical questions in a multi-disciplinary environment. The incumbent must keep abreast of current techniques within the field and the various scientific areas affecting dermatology, rheumatology, fibrosis, or respiratory disease.
SUPERVISION:
DIRECT and INDIRECT:
Supervises internal research as required. Also consultants and external experts as appropriate.
ACCOUNTABILITY:
The position is responsible for planning and executing research plans in the defined area of investigation., and for applying the acquired knowledge to the clinical research setting. This position has responsibility for the quality, quantity, timeliness, and scientific acceptability of translational development activities that result in reports that are submitted to regulatory authorities worldwide to support the approval of Celgene investigational and new drug applications and for the investigations necessary for internal decision-making.
CONTACTS: Principal recurring contacts, including their frequency and purpose.
INTERNAL:
Frequent contact with various levels of R&D as well as moderate contact with colleagues in other departments (drug discovery, clinical, regulatory, marketing, finance, business development) at Celgene is required.
EXTERNAL:
Moderate contact with, external experts and contractors, CRO's and laboratories, universities and appropriate professional groups as necessary.
WORKING ENVIRONMENT:
Domestic and international travel to company meetings and scientific conferences may be required.